A topoisomerase enzyme discovered more than a decade ago in an archaeal microorganism turns out to be distinct, both structurally and mechanistically, from any other known topoisomerase. Only four ...

Topoisomerases are classified into several families, namely, types IA, IB, IC, IIA and IIB. These families have different cellular roles and preferential substrate specificities. Topoisomerases are ...

Topoisomerase I (TOP1) enzymes are essential in higher eukaryotes, as they are required to relax DNA supercoiling generated by transcription, replication and chromatin remodelling. Topoisomerases are ...

Chromosomal translocations leading to chimeric oncoproteins are important in leukemogenesis, but how they form is unclear. We studied acute promyelocytic leukemia (APL) with the t(15;17) translocation ...

Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at the University of Seville in CABIMER) and with PharmaMAR, has identified ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding, published in ...

The current pandemic of COVID-19 has taken 1.5 million lives and counting while causing many more people to fall ill. Many studies have shown that adverse outcomes are related to excessive levels of ...

Avacta Life Sciences (Avacta Group plc) presented preclinical data on AVA-6103, a second-generation Precision peptide-drug conjugate, being developed for the potential treatment of cancer. AVA-6103 ...