Dynamic light scattering is frequently utilized to assess the quality of protein aggregation, degradation and solution. However, for high-throughput screening, conventional dynamic light scattering ...

Cell-surface proteins are critical therapeutic targets and are vital to cellular communication, signaling, and homeostasis.

Hydrogen/deuterium exchange-mass spectrometry (HDX-MS) is a powerful technique for studying protein dynamics, however its widespread application has been constrained by high sample consumption and ...

Fragment-based drug design (FBDD) has led to a revolution in contemporary drug discovery, facilitating a bottom-up approach to the identification and evolution of bioactive small molecules into viable ...

Researchers have created a platform, called SIMPL2, that revolutionizes the study of protein-protein interactions by simplifying detection while improving measurement accuracy. While protein-protein ...

Cytokine interaction networks drive immune function, but they are difficult to map and study. Not only are these networks complex, but they are built by molecules that typically exist in low ...

Swedish chemist Jöns Jacob Berzelius, in a letter to a fellow chemist, first suggested the name ‘proteins’ for a particular class of biological substances, deriving it from the Greek word proteios, ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

Biological targets represent a considerable test of our knowledge of the fundamental principles of molecular recognition. Effective modulation of biological events requires the generation of molecules ...